| Noun | 1. | Secretary of Health and Human Services - the person who holds the secretaryship of the Department of Health and Human Services; "the first Secretary of Health and Human Services was Patricia Roberts Harris who was appointed by Carter" |
| 2. | Secretary of Health and Human Services - the position of the head of the Department of Health and Human Services; "the post of Secretary of Health and Human Services was created by Congress in 1979" |