Splenetic

a.	1.	Affected with spleen; malicious; spiteful; peevish; fretful. You humor me when I am sick; Why not when I am splenetic? - Pope.
n.	1.	A person affected with spleen.

Adj.	1.	splenetic - of or relating to the spleen Synonyms: lienal, splenic
	2.	splenetic - very irritable; "bristly exchanges between the White House and the press"; "he became prickly and spiteful"; "witty and waspish about his colleagues" Synonyms: bristly, prickly, waspish

acerb, acerbate, acerbic, acid, acidic, acidulent, acidulous, acrimonious, adrenal, bearish, bitchy, bitter, blase, burning, cankered, cantankerous, caustic, choleric, churlish, crabbed, cranky, cross, cross-grained, crusty, cussed, disagreeable, dispirited, eccrine, embittered, endocrine, excitable, exocrine, fed-up, feisty, fractious, glandular, glandulous, gonadal, good and tired, holocrine, huffish, huffy, humoral, irascible, irked, irritable, jaded, life-weary, luteal, mean, melancholic, melancholy, merocrine, ornery, ovarian, pancreatic, perverse, prostatic, rancorous, rankled, resentful, resenting, satiated, sick, sick of, snappish, sore, spiteful, spleeny, stewing, testy, thymic, thyroidal, tired, tired of, tired of living, tired to death, ugly, virulent, waspish, wearied, weariful, weary, weary unto death, world-weary