| Noun | 1. | brain - that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cordSynonyms: encephalon |
| 2. | brain - mental ability; "he's got plenty of brains but no common sense" | |
| 3. | brain - that which is responsible for one's thoughts and feelings; the seat of the faculty of reason; "his mind wandered"; "I couldn't get his words out of my head" | |
| 4. | brain - someone who has exceptional intellectual ability and originality; "Mozart was a child genius"; "he's smart but he's no Einstein" | |
| 5. | brain - the brain of certain animals used as meat | |
| Verb | 1. | brain - hit on the head |
| 2. | brain - kill by smashing someone's skull |